Psychiatric Genetics Begins to Find Its Footing
نویسندگان
چکیده
منابع مشابه
Bringing genetics back to psychiatric endophenotypes.
t T he concept of endophenotypes, introduced almost 4 decades ago, has become increasingly important in the study of complex neuropsychiatric diseases. Endophenotypes are easurable, but not overtly observable, constructs in the pathway rom genetic variation to psychiatric disorder. As originally concepualized, endophenotypes must: 1) be associated with illness in the opulation; 2) be heritable;...
متن کاملPrinciples of Psychiatric Genetics
Genetic epidemiology The pioneering work of Böök, Sjögren, Angst, Perris, and others in Europe and Kallman, Heston, Rosenthal, Wender, and Kety in the United States firmly established the important role of genetic susceptibility factors in psychiatric disorders. Heston’s [1] original finding that adult offspring of hospitalized schizophrenic mothers had significantly higher rates of schizophren...
متن کاملPopulation stratification in European South-American subjects and its importance to psychiatric genetics research in Brazil.
92 • Revista Brasileira de Psiquiatria • vol 32 • no 1 • mar2010 References 1. Cordeiro Q, Souza BR, Correa H, Guindalini C, Hutz MH, Vallada H, RomanoSilva MA. A review of psychiatric genetics research in the Brazilian population. Rev Bras Psiquiatr. 2009;31(2):154-62. 2. Blaya C, Moorjani P, Salum GA, Goncalves L, Weiss LA, Leistner-Segal S, Manfro GG, Smoller JW. Preliminary evidence of asso...
متن کاملPsychiatric genetics, neurogenetics, and neurodegeneration
Neuropsychiatric disorders are common, complex, and severe disorders that affect the core of a person: their emotions, intellect, and ability to self-regulate. Millions of individuals worldwide suffer from these disorders; nevertheless, the factors that lead to the manifestation of symptoms are poorly understood. Neuropsychiatric disorders are characterized by heterogeneity, which means that di...
متن کاملMeta-analysis in psychiatric genetics.
The article reviews literature on methods for meta-analysis of genetic linkage and association studies, and summarizes and comments on specific meta-analysis findings for psychiatric disorders. The Genome Scan Meta-Analysis and Multiple Scan Probability methods assess the evidence for linkage across studies. Multiple Scan Probability analysis suggested linkage of two chromosomal regions (13q an...
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ژورنال
عنوان ژورنال: American Journal of Psychiatry
سال: 2019
ISSN: 0002-953X,1535-7228
DOI: 10.1176/appi.ajp.2019.19060643